Cortisone:

Cortisone is a type of steroid that is produced naturally by a gland in your body called the adrenal gland. Cortisone is released from the adrenal gland when your body is under stress. Natural cortisone is released into the bloodstream and is relatively short-acting.

Injectable cortisone is synthetically produced and has many different trade names (e.g. Celestone, Kenalog, etc.), but is a close derivative of your body’s own product. The most significant differences are that synthetic cortisone is not injected into the bloodstream, but into a particular area of inflammation. Also, the synthetic cortisone is designed to act more potently and for a longer period of time (days instead of minutes).

Cortisone knee injections can also be used in the treatment of auto accident injuries.

Joint Lubricants (Viscosupplementation):

Articular cartilage is the smooth coating covering the surface of the bones inside the knee. It helps to lubricate and cushion the surfaces of the knee joint. In osteoarthritis, this coating is damaged leading to reduced lubrication and cushioning. This results in some of the pain, grinding, and other symptoms experienced by osteoarthritis-sufferers (see the osteoarthritis section for further information).

Viscosupplementation therapy involves injecting a clear gel-like substance directly into the knee joint. These injections help to restore some of the lubrication lost by damaged cartilage and thus improve symptoms. An injection is given as one shot into the knee joint each week for three weeks. Usually people who respond to this form of treatment will experience some improvement for six to ten months. An injection series can be repeated every six months as needed. This method of therapy is used for people who have not benefited from less invasive therapies such as lifestyle modification, physiotherapy, and oral medications. The injections do carry a small risk of infection or allergic reaction to the lubricant itself. Physicians can provide additional information about the risks and benefits of this procedure.